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Effect of the Binding of Anti‐Zw a Antibodies on Platelet Function
Author(s) -
Leeuwen E.F.,
Leeksma O.C.,
Mourik J.A.,
Engelfriet C.P.,
Borne A.E.G. Kr.
Publication year - 1984
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1984.tb01599.x
Subject(s) - platelet , thrombasthenia , antibody , platelet membrane glycoprotein , glycoprotein , chemistry , fibrinogen , adenosine diphosphate , biochemistry , glanzmann's thrombasthenia , microbiology and biotechnology , immunology , medicine , platelet aggregation , biology
. Anti‐Zw a antibodies can induce a Glanzmann‐like platelet dysfunction in normal Zw a ‐positive platelets. Although a normal shape change and release reaction was always recorded in response to adenosine diphosphate and collagen, the aggregation on these inducers could be completely inhibited by anti‐Zw a antibodies. Analogous to the platelets from patients with Glanzmann's thrombasthenia, normal platelets sensitized with anti‐Zw a did not associate with fibrinogen upon exposure to adenosine diphosphate. Our data indicate that the binding site for fibrinogen is closely associated with the Zw a ‐antigenic determinants on the platelet membrane glycoproteins and thus with glycoprotein IIIa which is known to carry Zw a .