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Frequency and Clinical and Transfusional Significance of Rheumatoid Factor in Patients with Haemophilia and von Willebrand's Disease 1
Author(s) -
Celada Antonio,
Aguado M. Teresa,
Ortega Feliciano,
Magallon Manuel,
Villar Jose Martin,
Lambert Paul H.
Publication year - 1984
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1984.tb01597.x
Subject(s) - cryoprecipitate , haemophilia , medicine , haemophilia a , rheumatoid factor , haemophilia b , coagulopathy , von willebrand disease , von willebrand factor , rheumatoid arthritis , radioimmunoassay , gastroenterology , immunology , surgery , fibrinogen , platelet
Abstract. Using a solid‐phase radioimmunoassay for IgM rheumatoid factor, increased levels were found in 24% or 82 patients with haemophilia A, in 4 of 11 patients with haemophilia B, in 2 of 11 patients with haemophilia A with inhibitors and in 4 of 12 with von Willebrand's disease. The levels of rheumatoid factor increased significantly (p < 0.02) after factor VIII concentrate or cryoprecipitate transfusions. No clinical or transfusional side effects could be attributed in these patients in relation to the presence of rheumatoid factor.