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Response to Immunization with A and B Human Glycoproteins for the Procurement of Blood Grouping Reagents
Author(s) -
Contreras Marcela,
Armitage Susan E.,
Hewitt Patricia E.
Publication year - 1984
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1984.tb01590.x
Subject(s) - abo blood group system , antibody , immunization , immunology , potency , isoantibodies , glycoprotein , blood grouping , medicine , chemistry , biochemistry , in vitro
. 37 subjects have been immunized with A or B human blood group substances. All subjects showed at least a threefold increase in potency of their ABO antibodies. Use of the resulting plasma has considerably improved the quality of our ABO grouping reagents. The IgG component of these antibodies increased in all subjects and an IgA component was seen in the majority of post‐immunization samples. All group O subjects developed cross‐reacting anti‐A,B antibodies.