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A Rare Example of Weakened Expression of the Kell (K1) Antigen 1
Author(s) -
Kline William E.,
Sullivan Carolyn M.,
Bowman Robert J.
Publication year - 1984
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1984.tb01579.x
Subject(s) - antigen , medicine , immunology , microbiology and biotechnology , biology
. Random typing of donor units revealed a donor whose red blood cells gave very weak reactions with all anti‐Kell (anti‐K1) antisera. All other Kell‐system antigens (including Kx) and antigens of other red‐cell systems tested were normal. This weak K1 antigen was present in four generations of the donor's family. The red‐cell morphology is normal in all family members with the weakened K1 antigen. A consistent hypothesis is that the weak antigen is inherited through a variant allele at the Kell locus and represents a quantitative, not a qualitative, change.