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Red‐Cell Auto‐Antibodies Mimicking Anti‐Fy b Specificity
Author(s) -
Veer M.B.,
Leeuwen I.,
Haas F.J.L.M.,
Smelt M.,
Overbeeke M.A.M.,
Engelfriet C.P.
Publication year - 1984
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1984.tb01566.x
Subject(s) - antibody , autoantibody , b cell , microbiology and biotechnology , absorption (acoustics) , chemistry , immunology , medicine , biology , materials science , composite material
. An antibody is described, produced by an Fy(a+b‐) woman that at first reacted with her own cells, preferentially with Fy(b+) cells but not with Fy(a‐b‐) cells. Later, pure anti‐Fy b specificity occurred. Elution and absorption studies revealed that the antibody recognized a determinant absent from Fy(a‐b‐) cells but present on Fy(a+b‐) and Fy(a‐b+) cells, much more strongly, however, on the latter, and that it was an autoantibody.