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Serology and Genetics of an MNSs‐Associated Antigen Dantu
Author(s) -
Contreras Marcela,
Green Carole,
Humphreys June,
Tippett Patricia,
Daniels Geoff,
Teesdale Phyllis,
Armitage Susan,
Lubenko Anatole
Publication year - 1984
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1984.tb00102.x
Subject(s) - antigen , mendelian inheritance , biology , genetics , immunology , serology , antibody , gene
Dantu, a previously undescribed low‐incidence red cell antigen, is inherited as a Mendelian dominant character. The Dantu antigen is associated with very weak s antigen, protease resistant N antigen and either very weak or no U antigen. Two of the propositi had previously been shown to have an unusual hybrid MNSs sialoglycoprotein, and it is probably this which carries these unusual N, s and U antigens as well as the Dantu antigen. A study of the family of one propositus suggests, by conventional genetics, that Dantu is not controlled by the MNSs locus; a possible explanation is given. Several examples of anti‐Dantu are known, one was found to cause a positive direct antiglobulin reaction on neonatal red cells.