Premium
Normal Survival of Rh 0 (D) Negative, LW (a+) Red Cells in a Patient with Allo‐Anti LW a
Author(s) -
Cummings Elizabeth,
Pisciotto Patricia,
Roth Gerald
Publication year - 1984
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1984.tb00088.x
Subject(s) - medicine , titer , red cell , isotopes of chromium , mononuclear phagocyte system , gastroenterology , immunology , survival analysis , andrology , antibody
The serum of an Rh 0 (D)+ Caucasian female with a prior history of transfusions contained anti‐LW a , reacting moderately with Rh 0 (D)+ and weakly with Rh 0 (D) ‐ red cells at the antiglobulin phase. Since transfusions were required, Chromium ( 51 Cr) survival studies and mononuclear phagocyte assays (MPA) were used to predict in vivo survival. The MPA value of 6% of the positive control predicted a low likelihood of clinically significant extravascular destruction and 51 Cr survival studies indicated greater than 95% survival at 1 h and 78% survival at 20 h for rr erythrocytes. Transfusion of 4 units of Rh 0 (D) ‐ , serologically incompatible red cells increased the hemoglobin from 5.2 to 11.4 g/dl and the titer of anti‐LW a against rr red cells from 4 to 1,024 7 days after the transfusion. A second 51 Cr survival also indicated normal survival of rr erythrocytes. 3 additional Rh 0 (D) ‐ units were successfully transfused.