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An Investigation of Nonhemolytic Transfusion Reactions
Author(s) -
Decary F.,
Ferner P.,
Giavedoni L.,
Hartman A.,
Howie R.,
Kalovsky E.,
Laschinger C.,
Malette M.,
Martyres A.,
Mervart H.,
Naylor D.H.,
Rose J.E.M. St.,
Shepherd F.A.,
Tibensky D.
Publication year - 1984
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1984.tb00087.x
Subject(s) - medicine , incidence (geometry) , transfusion reaction , antibody , plateletpheresis , platelet , immunology , blood transfusion , gastroenterology , apheresis , physics , optics
This study was undertaken to document the incidence of immediate, nonhemolytic transfusion reactions and to identify a technique or set of techniques that would best identify the different causes of these reactions. A variety of tests were employed to detect lymphocyte, granulocyte, platelet and anti‐IgA antibodies. During this study 26,318 units of blood components were transfused on 5,030 occasions. 191 immediate, nonhemolytic reactions were experienced giving an incidence per unit of 0.73%. Blood specimens from 101 of these patients were investigated along with serum from 57 patients who showed no reaction to transfusion as controls. We show that standard B cell lymphocytotoxicity testing is the technique with which most antibodies can be detected (64% of reactors positive vs. 30% of controls, p<0.001). Additional tests did not significantly increase the level of antibody detection.