Premium
Transferrin Binding by Peripheral Blood Mononuclear Cells in Human Lymphomas, Myelomas and Leukemias
Author(s) -
Yeh ChangJing G.,
Taylor Colin G.,
Faulka W. Page
Publication year - 1984
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1984.tb00078.x
Subject(s) - dyscrasia , peripheral blood mononuclear cell , transferrin receptor , transferrin , multiple myeloma , receptor , lymphoma , leukemia , medicine , peripheral blood , immunology , hematology , microbiology and biotechnology , cancer research , biology , in vitro , biochemistry , plasma cell
Significantly more peripheral blood mononuclear cells (PBM) from 39 patients with lymphoma (p<0.001), myeloma (p<0.001), or leukemia (p<0.001–0.025) bind transferrin (Trf) than those of 23 normals. That Trf was bound to a receptor on these cells was shown by the inhibition of these cells bound to 125 I‐Trf with unlabeled Trf. The paucity of Trf receptors on PBM from normals and their presence on diseased cells prompt a suggestion that Trf receptors may offer a useful approach to the diagnosis and possible treatment of some blood dyscrasias.