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Evidence of Autonomous Red Cell Expression of Xg a Antigen in Human Bone Marrow Transplantation
Author(s) -
Sparkes Robert S.,
Crist Michol,
Sparkes Maryellen C.
Publication year - 1984
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1984.tb00062.x
Subject(s) - bone marrow transplantation , transplantation , antigen , bone marrow , immunology , red cell , human bone , cell , medicine , microbiology and biotechnology , biology , biochemistry , in vitro
Human bone marrow transplant chimeras afford the opportunity to determine whether a red blood cell antigen is autonomously controlled. Evaluation of an Xg(a‐) recipient and an Xg(a+) recipient, each transplanted with bone marrow of donors of opposite Xg a types, shows that the Xg a antigen is of the donor type following transplantation. This indicates that the Xg a antigen is controlled by the red blood cell, and confirms earlier studies in natural chimeras.