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Functional Antibacterial Activity of a Human Intravenous Immunoglobulin Preparation: in vitro and in vivo Studies
Author(s) -
Fischer Gerald W.,
Hunter Kenneth W.,
Hemming Val. G.,
Wilson Samuel R.
Publication year - 1983
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1983.tb04485.x
Subject(s) - antibody opsonization , antibody , in vivo , phagocytosis , in vitro , immunoglobulin g , microbiology and biotechnology , complement system , sepsis , immunology , medicine , chemistry , opsonin , biology , biochemistry
. The functional antibacterial activity of an intravenous immunoglobulin preparation (Swiss Red Cross Immunoglobulin, SRK‐Ig) was tested both in vitro and in vivo. Using type III group B streptococci as a model system, the intravenous immunoglobulin preparation was shown to enhance phagocytosis and killing of the bacteria by human neutrophils. There was good activity to several type III strains, and for efficient opsonization both antibody and complement were required. In an animal model of neonatal group B streptococcal sepsis, passively administered immunoglobulin enhanced survival with 27/37 (73%) treated animals surviving compared to only 3/16 (19%) controls. These studies demonstrate that the intravenous immunoglobulin preparation SRK‐Ig has retained functional activity and may have potential value for prophylaxis or therapy of certain bacterial infections.