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Studies on the Binding of IgG and F(ab) Anti‐A to Adult and Newborn Group A Red Cells
Author(s) -
Romano E.L.,
ZabnerOziel P.,
Soyano A.,
Linares J.
Publication year - 1983
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1983.tb01930.x
Subject(s) - bivalent (engine) , antibody , chemistry , microbiology and biotechnology , immunology , medicine , biology , organic chemistry , metal
. The values of the functional affinity constants for the binding of human IgG anti‐A and its F(ab) derivative with adult and newborn group‐A red cells have been determined. The values obtained for both monovalent and bivalent antibody with both types of cells were of the same order (about 1times10 8 M ‐1 ), indicating that IgG anti‐A binds to red cells only by one of its F(ab) arms.