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Detection of Lewis a Antigenic Determinants in Chinese Medicinal Herbs
Author(s) -
Wang X.M.,
Terasaki P. I.,
Loon J.,
Park M. S.,
Chia D.,
Bernoco D.
Publication year - 1983
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1983.tb01921.x
Subject(s) - carthamus , hemolysis , hemagglutination , traditional medicine , cytotoxicity , abo blood group system , antigen , chemistry , biology , biochemistry , in vitro , immunology , medicine
. Two Chinese medicinal herbs, Leonurus sibiricus L. and Carthamus tinctorius L., were found to have high levels of Lewis a (Le a )‐like determinants. The water‐soluble extracts specifically inhibited hemagglutination, hemolysis, and lymphocyte cytotoxicity directed against Le a . They did not inhibit Le b nor other specificities detected on lymphocytes, resulting from the interaction of Lewis, Secretor, and ABO systems such as A 1 Le b and A 1 Le d . The activity was nondialyzable, resistant to boiling and proteolytic enzymes, but was destroyed by periodate. It was suprising that an Le a substance, previously found in human secretions, was also present in flower abstracts.