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Posttransfusion Non‐A, Non‐B Hepatitis after Cardiac Surgery: A Prospective Study
Author(s) -
TurKaspa Ran,
Shimon Dov Victor,
Shalit Meir,
Adler Ruth,
Shraga Shmuel,
Manny Noga,
Morag Abraham,
Eliakim Marcel
Publication year - 1983
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1983.tb01919.x
Subject(s) - asymptomatic , medicine , hbsag , prospective cohort study , hepatitis , hepatitis b , disease , gastroenterology , liver disease , surgery , hepatitis c , incidence (geometry) , immunology , hepatitis b virus , virus , physics , optics
. In a prospective study of 50 recipients of HBsAg‐negative blood who had undergone cardiac surgery, 4 (8%) developed acute non‐A, non‐B hepatitis. The patients who developed hepatitis had received significantly more units of blood or blood products than the patients who had no hepatitis. The incubation period of the disease was 4–13 weeks, 3 patients were asymptomatic with peak alaminotransferase (ALT) levels of 320–497 U/l and 1 patient was jaundiced with a peak ALT of 3,400 U/l. 1 of the patients had high ALT levels after 21 weeks of observation, while 3 patients recovered after 7–10 weeks. It is concluded that non‐A, non‐B posttransfusion hepatitis in Israel is a medical problem similar to that in the USA and that the clinical picture of the disease varies from a mild asymptomatic to a symtomatic and protracted course.