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S‐Sulfonation: a Reversible Chemical Modification of Human Immunoglobulins Permitting Intravenous Application
Author(s) -
Gronski P.,
Hoftaetter T.,
Kanzy E. J.,
Lüben G.,
Seiler F. R.
Publication year - 1983
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1983.tb01899.x
Subject(s) - chemistry , immunoprecipitation , in vitro , in vivo , antibody , disulfide bond , chemical modification , molecule , cystine , reactivity (psychology) , cysteine , combinatorial chemistry , biochemistry , immunology , organic chemistry , medicine , enzyme , biology , alternative medicine , microbiology and biotechnology , pathology , gene
. S‐sulfonation represents a reversible chemical modification of disulfide bonds by which under the special conditions chosen only about 2.2 cystine units per IgG molecule are cleaved. Physicochemical and functional evidence for reconstititution is presented. Molecules reconstituted in vitro or in vivo regain, within a few hours, a reactivity (antigen binding, immunoprecipitation, Clq‐mediated cross‐linking of immune complexes) comparable to equimolar control preparations.