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Isoelectrofocusing in the Study of the Bf System: Existence of Two Common Subtypes of the Bf F Allele 1
Author(s) -
Geserick Gunther,
Patzelt Dieter,
Schröder Helga,
Nagai Tatsuo
Publication year - 1983
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1983.tb01882.x
Subject(s) - allele , immunofixation , locus (genetics) , genetics , microbiology and biotechnology , biology , gene , antibody , monoclonal , monoclonal antibody
. The inherited polymorphism of the properdin factor B (Bf system) was studied by isoelectrofocusing in polyacrylamide gel (PAGIF, pH range 5.0–8.0), followed by immunofixation. Using the described technique, two different subtypes of F bands are visible (designated as F‘ and F“). Studies of 13 families and 48 mother‐child pairs are not in contradiction to the assumption of a codominant inheritance by two alleles (Bf F ’ and B F” ) at a single locus.