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Non‐Centrifugal Plasma Collection Using Cross‐Flow Membrane Plasmapheresis
Author(s) -
Heal J.M.,
Bailey G.,
Helphingstine C.,
Thiem P.A.,
Leddy J.P.,
Buchholz D.H.,
Nusbacher J.
Publication year - 1983
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1983.tb01879.x
Subject(s) - plasmapheresis , complement system , membrane , titer , chemistry , complement (music) , cleavage (geology) , hemolysis , chromatography , immunology , medicine , biochemistry , biology , antibody , paleontology , complementation , fracture (geology) , gene , phenotype
. A prototype of a cross‐flow membrane plasmapheresis system was tested for its safety and efficacy in normal donors. 550 ml of plasma can be harvested in less than 1 h. The procedure appears to be safe for the donor. No significant alterations in donor hematological, coagulation, or biochemical values were obtained after the procedure compared to the predonation levels. Changes in the classical and alternate complement pathways were studied serially by analysis of functional hemolytic titers, C 3 and C 4 levels, and C 3 and factor B cleavage products. No firm evidence of complement activation by the polysulfone filtration cell membrane was found.