Premium
The Hey Antigen and Antibody: A Second Family Study and the First Example of an IgG anti‐Hey
Author(s) -
Strohm Patricia L.
Publication year - 1982
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1982.tb01114.x
Subject(s) - proband , antibody , antigen , hemolytic disease of the newborn (abo) , immunology , medicine , disease , biology , genetics , pregnancy , fetus , gene , mutation
A three generation family with 16 members shows that the Hey red blood cell antigen is not in the Rh, P or Kidd systems. The mother of the proband was found to have an IgG component in her anti‐Hey, probably the result of alloimmunization by her two Heypositive children. The wife of the proband who had 1 Hey‐positive child, and 4 recipients of a single unit of Hey‐positive blood did not have detectable anti‐Hey. The presence of the IgG component of the mother's anti‐Hey raises the possibility that both hemolytic disease of the newborn (HDN) and hemolytic transfusion reactions (HTR) could occur due to anti‐Hey.