Premium
Bg b Expression in Relation to the HLA‐B17 Antigen Splits Bw57 and Bw58 and the Cross‐Reactions of Anti‐Bg b Antibodies 1
Author(s) -
Pollack Marilyn S.,
Crawford Mary N.,
Robinson Harriet M.,
Berger Rachel,
Sabo Bernice,
O'Neill Geoffrey J.
Publication year - 1982
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1982.tb01109.x
Subject(s) - human leukocyte antigen , antigen , antibody , immunology , typing , ethnic group , microbiology and biotechnology , medicine , biology , genetics , sociology , anthropology
A substantial number of individuals typed as HLA‐B17 do not have Bg b . To determine whether or not this discrepancy reflects genetic or ethnic group differences or the influence of B17 antigen subtypes, a large number of unrelated and related B17 individuals from the Caucasian, Hispanic, Black and Chinese ethnic groups were tested in parallel for Bg b and Bw57‐ or Bw58‐ B17 subtype. Higher Bg b expression was found in association with Bw57, but differences in expression of Bg b were also seen in different ethnic groups and in different related individuals carrying the same Bw57 or Bw58 haplotype. Genetic factors other than HLA thus influence the expression of HLA antigens on red cells. Standard and antiglobulin lymphocytotoxicity tests indicate that all Bg b typing sera contain anti‐Bw57 antilymphocyte antibodies and most also contain anti‐Bw58 and cross‐reacting anti‐B12, B15 and/or Bw49 antibodies.