Premium
The Serology of Sd a Effects of Transfusion and Pregnancy
Author(s) -
Spitalnik Steven,
Cox Mary T.,
Spennacchio Janice,
Guenther Rita,
Blumberg Neil
Publication year - 1982
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1982.tb01104.x
Subject(s) - medicine , serology , titer , incidence (geometry) , pregnancy , antigen , antibody , obstetrics , immunology , first trimester , antibody titer , blood transfusion , gestation , biology , physics , optics , genetics
Pre‐ and posttransfusion antibody titers were performed on 6 patients with anti‐Sd a transfused with incompatible blood. In 3 of these patients a significant rise in IgG antibody titer was found. The data suggest that in occasional patients the Sd a antigen does evoke a secondary immune response. We evaluated 245 pregnant women for the presence of Sd a and found that 30% were Sd(a‐). This incidence was significantly higher than that found in normal blood donors (4%), but was lower than that described in previous reports. We found that 22% of pregnant women in their first trimester were Sd(a‐) whereas at term 36% were Sd(a‐). These significantly different incidences of antigen positivity suggest decreased antigen expression with progressing pregnancy, as seen in the Lewis system. No difference was found in the incidence of anti‐Sd a between pregnant women, either during their first trimester or at term, and normal donors.