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A Case Study
Author(s) -
Pegels J. G.,
Bruynes E.C.E.,
Altes H.R. Korthals,
Engelfriet C.P.,
Borne A. E. G. Kr.
Publication year - 1982
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1982.tb01097.x
Subject(s) - medicine , intensive care medicine
Abstract. Both 51 Cr‐survival studies with donor platelets and allogenic skin transplantations were performed in a patient with immune unresponsiveness to platelet antigens, i.e., HLA‐ and platelet‐specific antigens. The patient, who suffered from hypoplastic anaemia, was successfully transfused with random donor platelets during 13 months. The serum of this patient contained only granulocyte‐ and mononuclear‐cell‐reactive antibodies, but no platelet‐reactive antibodies. A nearly normal survival time of the donor platelets as well as a prolonged rejection time of a skin allograft of the same donor support the serological findings. The 51 Cr‐platelet survival time was not influenced by a leucocyte concentrate from the same donor, which was administered at the same time. Thus, in our patient, no increased platelet destruction could be induced via the so‐called innocent bystander mechanism.