Premium
Development of Multiple Antibodies in an Apparently ‘Protected’ Rh D Negative Mother
Author(s) -
Tovey L.A. Derrick,
Taverner J.M.,
Longster G.H.
Publication year - 1982
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1982.tb01082.x
Subject(s) - antibody , isoantibodies , medicine , rh blood group system , immunology
. A case is described of a group O Rh (D) negative woman who received a blood transfusion after the delivery of her first infant, blood group O Rh (D) negative. In her second pregnancy anti3 was detected, presumably due to the prior transfusion. The second infant was D+S+ and the direct antiglobulin test on this infant's cells was positive. As no anti‐D antibodies were detectable in this pregnancy, the positive antiglobulin test was presumably due to the anti‐S. Anti‐D immunoglobulin was administered after this pregnancy, but in spite of this the mother developed a strong anti‐D antibody. The significance of this ‘failure of protection’ is discussed in relation to the augmenting affect of antibody development during pregnancy.