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Alloantibody‐Induced Impaired Neonatal Expression of a Red Blood Cell Antigen Associated with Maternal Alloimmunization
Author(s) -
Ferguson S.J.,
Blajchman M.A.,
Guzewski H.,
Taylor C.R.,
Moulds J.
Publication year - 1982
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1982.tb01075.x
Subject(s) - antigen , immunology , cord blood , antibody , in utero , fetus , red blood cell , umbilical cord , titer , antiserum , obligate , biology , medicine , andrology , pregnancy , genetics , ecology
Animals genetically capable of making certain gene products have been shown to have the production of such products completely or partially suppressed by exposure in utero or neonatally to antibodies specific for that gene product. This alloantibody‐induced depression of expression of a specific antigenic determinant has yet to be shown to occur in man. The McCoy a red blood cell antigen is reported to be well developed at birth. However, 2 children born to mothers with high‐titer McCoy a antibodies in their serum, phenotyped as McCoy (a‐) at birth and, on retesting their red blood cells, 1 at 5 months and the 2nd at 11 months, both phenotyped as McCoy (a+). It is possible that this lack of expression of the McCoy a antigen at birth represents a characteristic of an obligate heterozygote. However, on testing 50 random umbilical cord red blood cell samples with two potent McCoy a antisera, only 1 was found to be negative. If the negative phenotpye were a characteristic of an obligate heterozygote at birth, then the neonatal incidence of the McCoy (a‐) phenotype should have been significantly (p<10 ‐4 ) higher in our random cord blood sample than observed (expected 11). The impaired expression of the McCoy a antigen on the red blood cells of these 2 infants at birth, in conjunction with evidence of maternal alloimmunization, strongly suggests alloantibody‐induced antigenic suppression of the McCoy a antigen as a probable cause.