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Chronic Cold Haemagglutinin Disease Due to an Anti‐M‐Like Autoantibody
Author(s) -
Chapman J.,
Murphy M.F.,
Waters A.H.
Publication year - 1982
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1982.tb00756.x
Subject(s) - autoantibody , haemolysis , immunology , titer , cold agglutinin , monoclonal , medicine , antibody , coombs test , hemolysis , monoclonal antibody , virology
. A case of chronic cold haemagglutinin disease due to an IgM monoclonal (kappa) autoantibody with anti‐M‐like specificity is described in a patient with the MN phenotype. The autoantibody was present in very high titre and active at body temperature, but haemolysis was only mild. The direct antiglobulin test was positive due to C 3 d on the patient's red cells, and the autoantibody was able to bind complement to normal MM and MN cells with a marked dosage effect.