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Management of Immune‐Mediated and Paraproteinemic Diseases by Membrane Plasma Separation and Cascade Filtration
Author(s) -
Valbonesi M.,
Garelli S.,
Montani F.,
Cefis M.,
Rossi U.
Publication year - 1982
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1982.tb00532.x
Subject(s) - filtration (mathematics) , immune system , immunology , cascade , chemistry , medicine , chromatography , mathematics , statistics
. Membrane plasma separation was utilized in the management of 19 patients with autoimmune, immune complex or paraproteinemic diseases. In these patients 34 procedures were carried out employing a new filter composed of polyvinyl alcohol hollow fibers with a nominal pore size of 0.4 μm. Cascade filtration was performed in 23 procedures using a second filter built up with ethylenevinylalcohol copolymer hollow fibers with a nominal pore size of 0.1–0.2 μm. Both filters employed showed a very good biocompatibility, and no untoward effect was observed. Using the differential sieving effect of cascade filtration it was possible to eliminate circulating immune complexes and immunoglobulin M without the loss of necessary plasma components.