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Importance of IgG Subclasses of Anti‐Rh Antibodies for the Detection of Fc‐Receptor‐Bearing Human Lymphocytes
Author(s) -
Zupańska Barbara,
Maślanka Krystyna,
Loghem Erna
Publication year - 1982
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1982.tb00019.x
Subject(s) - antibody , immunology , receptor , fc receptor , immunoglobulin g , bearing (navigation) , medicine , computer science , artificial intelligence
13 anti‐Rh sera were compared for their usefulness in the detection of Fc‐receptor‐bearing lymphocytes (EA hum test). IgG subclasses of anti‐Rh antibodies were determined by the antiglobulin test with monospecific sera and by the detection of Gm allotypic markers in the haemagglutination inhibition test. Six sera with IgG 1 + IgG 3 or IgG 1 + IgG 2 + IgG 3 antibodies and one with pure IgG 3 antibodies were found to be useful, whereas six other sera with only IgG 1 were unsuitable for the EA hum test. G3m markers were detected only on the anti‐Rh antibodies which were capable of forming rosettes with lymphocytes. The data show that human peripheral lymphocytes possess Fc receptors for IgG 3 immunoglobulins.