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Prothrombin Complex Concentrates for Clinical Use 1
Author(s) -
Chandra S.,
Brummelhuis H.G.J.
Publication year - 1981
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1981.tb01048.x
Subject(s) - prothrombin complex , thrombogenicity , medicine , factor ix , intensive care medicine , prothrombin complex concentrate , surgery , coagulation , thrombosis , warfarin , atrial fibrillation
Prothrombin complex concentrates prepared for clinical use are reviewed with emphasis on frequently observed adverse reactions such as viral hepatitis and thromboembolic complications. Preparation procedures and quality control are described briefly, and the use of these concentrates in the treatment of hemophilia A patients who develop factor VIII inhibitors is also described. The causes of and methods for the detection of potential thrombogenicity are discussed and suggestions which may result in a safer product are made.