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Detection of Anti‐Varicella‐Zoster Virus Antibodies in Blood Donors by Automated Passive Haemagglutination
Author(s) -
Chung A.,
Naylor D.H.
Publication year - 1981
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1981.tb01044.x
Subject(s) - autoanalyzer , antibody , hemagglutination , virology , immunofluorescence , medicine , virus , varicella zoster virus , indirect immunofluorescence , immunology
1,219 normal blood donors were screened for anti‐varicella‐zoster virus antibodies by automated passive haemagglutination (APH) on a Technicon TM 15‐channel Auto Analyzer. 98 samples (8%) were positive by APH and 92% of these were shown to have antibody titres ≧ 1/16 by indirect immunofluorescence assay (IFA). Parallel testing of an additional 265 donors revealed that 11 (4%) individuals had IFA titres ≧ 1/64 and 6 of these 11 donors were identified by APH. Thus, APH is an effective means of rapidly detecting units of plasma acceptable for production of varicella‐zoster immunoglobulin.