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Discovery of a Cytoplasmic‐Dominant Alloantigen Prevalent in Erythrocytes
Author(s) -
Neurath A.R.,
Strick N.,
Rowe A. W.,
Rubinstein P.,
Fotino M.
Publication year - 1981
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1981.tb01036.x
Subject(s) - antigen , cytoplasm , radioimmunoassay , antibody , immunology , biology , isoantigens , medicine , genetics , biochemistry
An alloantigen was detected in the cytoplasm of blood cells, predominantly in hemolyzed erythrocytes, by radioimmunoassays developed with antibodies from a hemophiliac. The frequency of the antigen varies in different races. Studies in Caucasian families revealed an autosomal‐dominant inheritance of the antigen.