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Model for the Rh Blood Group System Based on Discontinuous Gene Structure
Author(s) -
Giorno Ralph
Publication year - 1981
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1981.tb01022.x
Subject(s) - exon , intron , gene , genetics , biology , microbiology and biotechnology
A model of the Rh blood group system is proposed which is based on discontinuous gene structure. The R 29 control subregion consists of a single exon flanked by introns. Following the R 29 subregion, the R 1 subregion exists as seven exon structures which alternate with introns. The expression of each exon is controlled by flanking introns. A separate exon‐intron structure controls expression of the Rh: ‐1 phenotype. Differential gene expression is controlled by intron sequences and complementary splicer RNA sequences encoded by unlinked loci.