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Does Anti‐Jr a Cause Hemolytic Disease of the Newborn?
Author(s) -
Toy P.,
Reid M.,
Lewis T.,
Ellisor S.,
Avoy D. R.
Publication year - 1981
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1981.tb01010.x
Subject(s) - hemolytic disease of the newborn (abo) , medicine , disease , isoantibodies , intensive care medicine , pediatrics , immunology , pregnancy , antibody , biology , fetus , genetics
. A Jr(a‐) Japanese female developed anti‐Jr a during her first pregnancy. Both father and infant red cells were Jr(a+), and anti‐Jr a was eluted from the infant's red cells. The antibody was determined to be IgGl. Hemolysis could not be definitively established from the clinical data. The pitfall of using the presence of jaundice as the sole evidence for hemolysis is emphasized. We conclude that the present case, and other previously reported cases, do not unequivocally establish that anti‐Jr a causes significant hemolytic diesease of the newborn (HDN). Amniocentesis probably should not be performed during the pregnancy of mothers sensitized to Jr a antigen. Jr a HDN is probably a mild disease, like ABO HDN.