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A Patient with Post‐Hepatitis B Immune Deficiency: Nonspecific Helper Factor Partially Restores the in vitro Immune Response 1
Author(s) -
Sheehy Michael J.,
Miller Nanci J.,
Rappeport Joel M.,
Gozes Yehoshua,
Parkman Robertson,
Strom Terry B.,
Yunis Edmond J.
Publication year - 1981
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1981.tb00719.x
Subject(s) - immunology , immune system , cytotoxic t cell , t helper cell , lymphokine , in vitro , monoclonal antibody , aplastic anemia , biology , antibody , t cell , microbiology and biotechnology , bone marrow , biochemistry
. A patient with severe post‐hepatitis B aplastic anemia had depressed B and T cell responses. In mixed leukocyte culture, her cells were unresponsive to unrelated control stimulating cells, but responded well to a pool of cells from the same unrelated controls. She had reduced production of lymphocyte mitogenic factor (MF), suggesting a helper cell defect, and she had few or no cells reactive with the monoclonal anti‐T cell antibodies OKT3, OKT4 or OKT5. Her cells proliferated in response to MF produced by a pool of cells without mitogen, however. Furthermore, her cells became specifically cytotoxic when stimulated by cells plus MF, but not when stimulated by either cells or MF alone. Thus her T cell deficiency was correctable by nonspecific helper factor in vitro.