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Intravascular Hemolytic Transfusion Reaction due to Anti‐Vw+Mi a with Fatal Outcome
Author(s) -
Molthan Lyndall
Publication year - 1981
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1981.tb00678.x
Subject(s) - medicine , antigen , antibody , transfusion reaction , red blood cell , blood transfusion , immunology , immune system , red blood cell transfusion , isoantibodies , red cell
. Because of the increasing use of type, screen and hold protocols and minimal surgical blood order protocols in transfusion services, a number of patients are receiving un‐cross‐matched blood in elective situations. There are many low‐frequency red blood cell antigens which are lacking on reagent cells used for antibody screening procedures, and alloantibodies directed against these antigens are relatively common and occur in either natural or immune forms. A case of an intravascular hemolytic transfusion reaction resulting in death is reported. The patient had a naturally occurring anti‐Vw+Mi a and received 1U of Vw+Mi a ‐positive donor red cells. It is the 1st documented case of a hemolytic transfusion reaction due to this incompatibility. The potential threat of transfusion reactions due to low‐frequency antigens must be recognized by the physicians who design type, screen and hold protocols and it has particular reference to the selection of possible recipients for whom the protocols are applied.