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An Improved Method for the Preparation of Intermediate‐Purity Antihemophilic Factor Concentrate for Therapeutic Usage
Author(s) -
Liu Daniel T. H.,
Irwin J. F.,
LeFave R. O.,
Grzenczyk B.,
Pai R. C.
Publication year - 1980
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1980.tb02357.x
Subject(s) - solubility , potency , chromatography , medicine , chemistry , pharmacology , biochemistry , in vitro , organic chemistry
. An improved method involving pH changes in the process for the preparation of intermediate‐purity antihemophilic concentrate offers several advantages over the standard method. Antihemophilic concentrates thus prepared are more soluble, more purified and more stable than the standard antihemophilic concentrates. High‐potency antihemophilic concentrates with good solubility may be obtained by concentrating the [in‐process] solution before lyophilization.