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Comparative Automated Assay of Anti‐P 1 Antibodies in Acute Hepatic Distomiasis (Fascioliasis) and in Hydatidosis
Author(s) -
BenIsmail R.,
Rouger P.,
Carme B.,
Gentilini M.,
Salmon C.
Publication year - 1980
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1980.tb02345.x
Subject(s) - antibody , medicine , helminthiasis , echinococcosis , immunology , gastroenterology , pathology
. An automated assay of anti‐P 1 allohemagglutinins has been carried out on 133 P 2 subjects: 13 with acute hepatic distomiasis (Fascioliasis), 20 with hydatidosis and 100 healthy blood donors. Anti‐P 1 were detected in 100% of the distomatid sera, in 50% of the hydatid and in 29% of the healthy individuals. When compared to a reference serum test (anti‐P 1 standard), their concentration was found to be weak in healthy subjects, moderate in hydatidosis and exceptionally increased in acute distomiasis (up to 5–6 times the standard anti‐P 1 level). The 2‐mercaptoethanol treatment showed that even the increased distomatid anti‐P 1 sera were of an IgM nature. The respective origin, synthesis and strength of these allohemagglutinins are discussed and the advantages of using distomatid IgM anti‐P 1 as human sera test are emphasized.