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Increased Incidence of Haemolytic Disease of the New‐Born Caused by ABO‐Incompatibility when Tetanus Toxoid is Given during Pregnancy
Author(s) -
Gupte S. C.,
Bhatia H. M.
Publication year - 1980
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1980.tb02326.x
Subject(s) - toxoid , tetanus , medicine , pregnancy , incidence (geometry) , neonatal tetanus , abo blood group system , jaundice , immunology , obstetrics , pediatrics , vaccination , surgery , biology , genetics , physics , optics
. To determine whether tetanus toxoid given during pregnancy increases the risk of haemolytic disease of the new‐born, 818 group 0 pregnant women were given one to three doses of tetanus toxoid during the third trimester. There was a significant increase in the incidence of neonatal jaundice among the ABO‐incompatible infants of women given toxoid, compared to a control group. Comparative studies were also done at two hospitals: tetanus toxoid was not given during pregnancy at one hospital and was used routinely at the other. More of the mothers given toxoid had high titres of igG anti‐A or anti‐B and more of their ABO‐incompatible infants became jaundiced. Thus these studies suggest an increased risk of haemolytic disease of the new‐born due to ABO incompatibility when tetanus toxoid injections are given during pregnancy.