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Detection of Penicillins in the Sera of ‘Healthy’ Blood Donors
Author(s) -
Michel J.,
Sharon R.
Publication year - 1980
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1980.tb02325.x
Subject(s) - penicillin , bioassay , bacillus subtilis , microbiology and biotechnology , medicine , cephalosporin , antibiotics , chemistry , immunology , biology , bacteria , genetics
. 10,853 sera, collected from ‘healthy’ blood donors during the period December 1977 to May 1979, were tested for the presence of penicillinase‐sensitive penicillins by a bio‐assay technique using Bacillus subtilis ATCC 6633 as test organism. Their presence could be demonstrated in 30 sera (0.27%), at concentrations equivalent to 0.2–4.0 μg/ml of penicillin G. The implications of these findings are discussed, particularly the possibility of their relationship to nonhemolytic adverse reactions to transfusion.