Premium
Analbuminemia: Report of a Case and Review of the Literature 1
Author(s) -
Dammacco Franco,
Miglietta Antonio,
D'Addabbo Angelo,
Fratello Angelo,
Moschetta Raffaele,
Bonomo Lorenzo
Publication year - 1980
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1980.tb01851.x
Subject(s) - albumin , medicine , serum albumin , edema , acute phase protein , endocrinology , gastroenterology , physiology , inflammation
Idiopathic analbuminemia was fortuitously detected in a 30‐year‐old Italian woman. No associated disease condition could be revealed in this patient, the only consistent finding being a slight tendency to develop ankle edema. Asthenia and a moderate hypotension were also recorded. Trace amounts (5.2 mg/100 ml) of serum albumin were determined by immunochemical methods. Laboratory features also included increased circulating levels of cholesterol and β‐lipoproteins, as well as elevation of acute phase reactants and immunoglobulins. Albumin turnover studies showed low albumin synthesis and abnormally slow albumin degradation rate. No consanguinity of the parentage could be traced in this patient and an autosomal recessive transmission of the trait was suggested. An extensive review of the literature disclosed 19 additional cases of this rare condition, their occurrence actually challenging the vital role of albumin in man. Compensatory mechanisms certainly play a role but are only partially understood.