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Suppression of Early Rhesus Sensitization by Passive Anti‐D Immunoglobulin:Suppression of Early Rhesus Sensitization
Author(s) -
Tovey L. A. Derrick,
Scott James S.
Publication year - 1980
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1980.tb01850.x
Subject(s) - sensitization , immunology , antibody , rh blood group system , medicine , cord blood , coombs test , pregnancy , isoantibodies , biology , genetics
Anti‐D immunoglobulin is an effective prophylactic against rhesus isoimmunization. It is generally regarded as ineffective once antibody production has developed though there have been a number of inconclusive reports suggesting it may suppress early sensitization. Anti‐D (100μg) was given after delivery of a rhesus (D) positive child to a rhesus (D) negative mother who was shown to have anti‐D antibodies at that time by five tests on two separate specimens in two different laboratories and by a weakly positive direct anti‐globulin test on the cord blood. In a further pregnancy with a rhesus (D) positive child no antibody was detected by multiple tests including enzyme technique.