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Heterophile Antibodies in the Serum of Children with Nephrotic Syndrome 1
Author(s) -
Satoh Paul S.,
Elberg Alfredo J.,
Fleming William E.,
Baluarte H. Jorge,
Gruskin Alan B.
Publication year - 1980
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1980.tb01847.x
Subject(s) - antibody , heterophile , nephrotic syndrome , horse , mononucleosis , medicine , immunology , guinea pig , titer , antibody titer , biology , virus , paleontology
Serum of children with the nephrotic syndrome contained high titers of a (19s) IgM antibody against sheep, horse, guinea pig, rat, and rabbit red blood cells but not against cow red blood cells. There was high correlation between high titers of antisheep antibodies and active nephrotic syndrome in the children with minimal change nephrotic syndrome. The antibody differed from the Paul‐Bunnell antibody found in patients with infectious mononucleosis and from the anti‐Forssman, Hangautziu‐Deicher antibody found in patients with horse serum sickness. Rabbit red blood cells completely absorbed the antibody, but horse or guinea pig red blood cells removed only the anti‐Forssman activity.