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Comparison of Six ‘Third‐Generation’ Tests for the Detection of HBsAg
Author(s) -
Reesink H. W.,
LafeberSchut L. J. Th.,
Aaij C.,
ReerinkBrongers E. E.
Publication year - 1980
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1980.tb01839.x
Subject(s) - hbsag , centrifugation , third generation , chromatography , medicine , chemistry , virology , virus , hepatitis b virus , computer science , telecommunications
. Six ‘third‐generation’ techniques for the detection of HBsAg were compared, i.e. Ausria 11–125, Travenol‐RIA, Auszyme, Hepanostika, Auscell and a modified Auscell technique applying centrifugation instead of sedimentation. The Ausria 11–125 was the most sensitive test, followed by Travenol‐RIA, both Auscell techniques, Auszyme and Hepanostika. In the Ausria 11–125, Hepanostika and Auscell techniques, 1–2% of false‐positive results were found in serum and 2% in plasma specimens from blood donors. Both the Travenol‐RIA and Auszyme tests gave an unacceptably high percentage (6–8%) of false‐positive results in both serum and plasma specimens.