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Blood Transfusions and Antibody Response in Patients Waiting for a Kidney Transplant 1
Author(s) -
WernerFavre Christiane,
Jeannet Michel
Publication year - 1980
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1980.tb01831.x
Subject(s) - medicine , antibody , blood transfusion , kidney transplantation , immunology , platelet , absorption (acoustics) , kidney , materials science , composite material
Cold and warm B and T cell antibodies have been investigated following blood transfusion in patients waiting for a kidney transplant. 18 out of 28 patients were sensitized after a single transfusion: half of them presented a B‐warm pattern and the other half either a T‐warm or a B‐cold pattern. Several sera collected after one transfusion were absorbed with pooled platelets. All three T‐warm sera have become negative after absorption. Out of 21 B‐warm sera, 6 remained B‐warm, 3 became B‐cold and 12 were negative after absorption. There was no difference in strength between the B‐warm sera which were absorbed and those which resisted to absorption. Dilution studies showed that sera followed a similar trend: they convert from T‐warm to B‐warm and B‐cold patterns. Sequential sera from patients receiving systematic transfusions were tested at regular intervals after each transfusion. Most patients produced B‐warm antibodies.