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Enhanced Yield of Antihemophilic Factor and von Willebrand Factor by Cryoprecipitation with Polyethylene Glycol 1
Author(s) -
Johnson Alan J.,
Macdonald Valerie E.,
Brind Joel
Publication year - 1979
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1979.tb04401.x
Subject(s) - yield (engineering) , von willebrand factor , polyethylene glycol , chemistry , immunology , medicine , platelet , biochemistry , materials science , metallurgy
. A procedure involving cryoprecipitation of human plasma in the presence of polyethylene glycol results in consistently higher yields of antihemophilic factor and von Willebrand factor than were heretofore achieved by cryoprecipitation alone. The resulting AHF and vWF are at least as pure as ordinary cryoprecipitate and can easily be further purified by additional processing. The method is expected to be especially useful in the preparation of AHF and vWF concentrates for the treatment of patients with hemophilia or von Willebrand's disease.