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HLA, DRW (IA‐Like) and Additional Surface Antigens Expressed on Adenoid T and B Lymphocytes 1
Author(s) -
Gazit E.,
Mizrahi Y.,
Orgad S.,
Efter T.,
Lewenstein M.,
Ostfeld E.
Publication year - 1979
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1979.tb02291.x
Subject(s) - adenoid , antigen , immunology , human leukocyte antigen , titer , lymphocyte , antibody , peripheral blood , biology
. Pregnancy sera were found to react differently when screened simultaneously with adenoid and peripheral blood lymphocytes (PBL) obtained from the same individual. Some of the reactions were attributed to the higher sensitivity of adenoid lymphocytes to a low titer HLA or Ia antibody, while others were shown to be due to the expression of DRw (Ia‐like) antigens on both T and B lymphocytes separated from adenoids. Positive reactions specific to adenoid lymphocytes, or manifested only following anti‐β 2 ‐microglobulin (a‐β 2 ‐m) treatment, suggest the presence of antigens other than HLA or Ia on the cell membrane. Unmasking of antigenic sites by the a‐β 2 ‐m capping process and rearrangement of the membrane structure may also contribute to the observed phenomena.