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Clonal Proliferation of Lymphoid and Myeloid Progenitor Cells in Patients with Hematological Abnormalities 1
Author(s) -
Górski Andrzej,
RokickaMilewska Roma,
Litwin Joanna,
KolakowskaPolubiec Krystyna,
Madaliński Kazimierz
Publication year - 1979
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1979.tb02275.x
Subject(s) - aplastic anemia , lymphatic system , myeloid , immunology , progenitor cell , cfu gm , stem cell , lymphoproliferative disorders , biology , leukemia , haematopoiesis , myeloid leukemia , anemia , medicine , lymphoma , bone marrow , genetics
. Myeloid and lymphoid stem cell colony formation (GM‐CFU and L‐CFU) was studied in patients with lymphoproliferative diseases, aplastic anemia and other hematological abnormalities. Most patients with acute lymphatic leukemia had low number of L‐CFU with decreased or normal GM‐CFU, while in Hodgkin's disease and chronic lymphatic leukemia L‐CFU growth was very poor with only minor abnormalities of GM‐CFU formation. Aplastic anemia was characterized by a decreased CM‐CFU and normal L‐CFU. Coculture studies suggested that a diminished colony formation may be linked to circulating lymphocytes that inhibit L‐CFU as well as the reduction in number of precursor cells.