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Changes in the Inhibition of Specific Agglutination by Plasma Due to Microvesicles Released from Human Red Cells during Storage for Transfusion
Author(s) -
Cole Wendy F.,
Rumsby Martin G.,
Longster George H.,
Tovey L. A. Derrick
Publication year - 1979
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1979.tb02273.x
Subject(s) - microvesicles , echinocyte , glycophorin , agglutination (biology) , red cell , red blood cell , chemistry , membrane , microvesicle , biology , antigen , microbiology and biotechnology , biochemistry , immunology , medicine , microrna , gene
. The progressive appearance of erythrocyte antigenic activity in plasma from donations of human blood taken into acid citrate‐dextrose (ACD) and stored at 4°C for transfusion has been studied. It has been shown by specific inhibition tests that A, B, H and P 1 activities are associated with membrane‐bounded microvesicles which are released from the red cell membrane during the disc‐echinocyte‐spherocyte shape transformation. Although M group activity appears to be lost from the red cell membrane during storage, significant recovery on the microvesicles is not obtained even though these seem to contain the M and N group intrinsic protein, glycophorin.