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Variation of Cold Agglutinin Levels
Author(s) -
Dube Volker E.,
Zuckerman Leon,
Philipsborn Herbert F.
Publication year - 1978
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1978.tb03725.x
Subject(s) - cold agglutinin , titer , agglutinin , cold agglutinin disease , biology , immunology , zoology , medicine , antibody , lectin , autoantibody
. Cold agglutinin levels were determined in 120 individuals ranging in age from 1 to 64 years using untreated and ficin‐treated group O erythrocytes. The geometric mean titer for untreated cells was 5.7±1.1 SEM and for ficin‐treated cells 18.7±1.1 SEM. The mean titers and scores for various blood groups were not significantly different. Titers and scores correlated significantly to total serum IgM concentration (p<0.001). Females had significantly higher cold agglutinin levels than males (p<0.001). A significant decrease of cold agglutinins occurred in the 26‐ to 64‐year age group as compared to the 11‐ to 25‐year age group (p<0.01). The data should contribute to a clearer understanding of the biological impact of cold agglutinins.