Premium
A Study of Different Rhesus Phenotypes and their Binding Characteristics
Author(s) -
Morley G.
Publication year - 1978
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1978.tb02952.x
Subject(s) - autoanalyzer , phenotype , binding site , chemistry , microbiology and biotechnology , isoantigens , antigen , biology , genetics , gene , chromatography
. A method has been developed using the AutoAnalyzer to study the binding characteristics of anti‐D with cells of various rhesus phenotypes. A positive association has been demonstrated between site density and association constant. A hypothesis is proposed for the presence of two types of antigenic sites on the cell surface recognised only by affinity differences. The higher affinity site binds both arms of an IgG anti‐D molecule, whereas the lower affinity site binds only one.