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Increased Frequency of HLA‐DRW4 in Chronic Active Hepatitis 1
Author(s) -
Williams R. Michael,
Martin Sharon,
Falchuk Kenneth R.,
Trey Charles,
Dubey Devendra P.,
Cannady William G.,
Fitzpatrick Donna,
Noreen Harriet,
Dupont Bo,
Yunis Edmond J.
Publication year - 1978
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1978.tb02948.x
Subject(s) - human leukocyte antigen , liver biopsy , medicine , locus (genetics) , hepatitis , immunology , typing , peripheral blood , chronic hepatitis , biopsy , gastroenterology , antigen , biology , genetics , gene , virus
. HLA‐A, B, C and DRw typing was performed on peripheral blood lymphocytes of 17 adults with the diagnosis of chronic active hepatitis made by liver biopsy as the only criterion for study. An increase in the frequency of HLA‐DRw4 (71 vs. 24%, p<0.005) was observed, but there was no increased frequency of HLA‐A1, B8 or any other HLA locus specificity.