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Relationship between Maternal Anti‐D Levels, Fetal Phenotype and Haemolytic Disease of the Newborn
Author(s) -
Morley G.
Publication year - 1978
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1978.tb02942.x
Subject(s) - haemolytic disease , phenotype , fetus , medicine , clinical phenotype , disease , isoantibodies , pregnancy , immunology , obstetrics , antibody , biology , genetics , gene
. It has been demonstrated that a lower level of maternal anti‐D is required to produce the same symptoms of haemolytic disease of the newborn in R 2 r infants than in R 1 r infants. This difference could be explained by postulating that the higher site density of R 2 r cells is associated with an increased association constant and thus will bind sufficiently more anti‐D. The level at which amniocentesis should be considered has been calculated to be 1.44 μg anti‐D/cm 3 of maternal serum for R 1 r infants and 0.73 for R 2 r infants.